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| tcsgroups | Дата: Воскресенье, 26.06.2016, 10:45 | Сообщение # 755 |
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| Docetaxel (as generic or underneath the job eminence Taxotere) is a clinically well-known anti-mitotic chemotherapy medication (medication which interferes with stall allotment). It is acclimated to mostly for the treatment of knocker, ovarian, prostate, and non-small cell lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved be entitled to as a service to treatment of patients who partake of locally advanced, or metastatic breast or non small-cell lung cancer who suffer with undergone anthracycline-based chemotherapy and failed to hold back cancer advance or relapsed[4 - and a European rubber stamp for licence in hormone-refractory prostate cancer.[5 -
According to a 2005 article in the magazine Drugs, docetaxel administered as a one-hour infusion every three weeks commonly as surplus a ten cycle dispatch, docetaxel is considered as or more real than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - No matter what the effectiveness of docetaxel versus paclitaxel and other taxanes is stilly controversial. Diverse more brand-new articles father build "no sign that regimens containing docetaxel cry quits greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week charge register used to be and is at rest considered efficient but chic studies are indicating a weekly outline effect be better. A 2010 article in On the qui vive Clinical Pharmacology states, "weekly charge has emerged as the optimal schedule." Docetaxel is marketed worldwide subordinate to the identify Taxotere nearby Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.[citation
Properties
Docetaxel is of the chemotherapy knock out class; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an extract from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Due to scarcity of paclitaxel, vast delving was carried visible foremost to the formulation of docetaxel – an esterified artefact of 10-deacetyl baccatin III, which is extracted from the renewable and agreeably ready European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl useful coterie on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side gyve in place of of the benzyl amide in paclitaxel. The carbon 10 functioning organize change causes docetaxel to be more water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a snowy coat capacity and is the working ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The mixing is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL disinfected pyrogen-free anhydrous polysorbate 80, and a distinct dosage Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose in the interest administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and financially sound vials are combined to bestow a unravelling of 10 mg/mL and the required measure is drawn from this solution. Vials have in the offing an overfill to even up as a replacement for fluid impoverishment during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored for 24 months here 25 °C away from light and 80 mg vials for 26 months in the anyhow conditions.[8 -
Recently Sanofi has got authorization for one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion answer is simplified by eliminating the before dilution step. The two-vial and one-vial formulations restrict the unchanged stimulant pith, docetaxel trihydrate, and the same excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the same psychedelic theme in the selfsame concentration as the already approved two-vial formulation. The in spite of form, superiority, and sum of polysorbate 80 are closest in the infusion elucidation of both formulations. The solely argument between these two formulations is the measure of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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| tcsindustryj | Дата: Среда, 06.07.2016, 08:45 | Сообщение # 756 |
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Группа: Гости
| Docetaxel (as generic or subservient to the trade eminence Taxotere) is a clinically traditional anti-mitotic chemotherapy medication (medication which interferes with apartment compartmentation). It is worn mainly payment the treatment of heart, ovarian, prostate, and non-small cell lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved be entitled to representing treatment of patients who arrange locally advanced, or metastatic breast or non small-cell lung cancer who procure undergone anthracycline-based chemotherapy and failed to put an end cancer advance or relapsed[4 - and a European rubber stamp to work in hormone-refractory prostate cancer.[5 -
According to a 2005 article in the magazine Drugs, docetaxel administered as a one-hour infusion every three weeks commonly over a ten recur track, docetaxel is considered as or more basic than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - Respect the effectiveness of docetaxel versus paclitaxel and other taxanes is stilly controversial. A variety of more late-model articles procure build "no confirmation that regimens containing docetaxel raise the white flag greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week dispensation list hardened to be and is until now considered operative but hip studies are indicating a weekly outline influence be better. A 2010 article in Current Clinical Pharmacology states, "weekly charge has emerged as the optimal schedule." Docetaxel is marketed worldwide under the high regard Taxotere by Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.[citation
Properties
Docetaxel is of the chemotherapy opiate class; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Apt to scarcity of paclitaxel, vast study was carried out primary to the formulation of docetaxel – an esterified output of 10-deacetyl baccatin III, which is extracted from the renewable and promptly available European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl useful group on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side string in place of of the benzyl amide in paclitaxel. The carbon 10 functional group mutation causes docetaxel to be more water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a pale-complexioned coat capacity and is the strenuous ingredient at one's disposal in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The answer is a discernibly brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL unproductive pyrogen-free anhydrous polysorbate 80, and a singular amount Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion case containing 0.9% sodium chloride or 5% glucose recompense administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and profitable vials are combined to pay a colloidal suspension of 10 mg/mL and the required dispense is haggard from this solution. Vials have an overfill to balance as a replacement for fluid harm during preparation, foaming, adhesion to vial walls and the uninteresting volume. 20 mg vials may be stored to 24 months here 25 °C away from insight and 80 mg vials since 26 months in the same conditions.[8 -
Recently Sanofi has got approval because of one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion emulsion is simplified nearby eliminating the blue ribbon dilution step. The two-vial and one-vial formulations carry the at any rate dose pith, docetaxel trihydrate, and the uniform excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous settling that contains the same tranquillizer substance in the after all is said concentration as the already approved two-vial formulation. The unmodified grade, quality, and quantity of polysorbate 80 are proximate in the infusion revelation of both formulations. The however unlikeness between these two formulations is the measure of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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| famuyiyaoq | Дата: Вторник, 20.09.2016, 02:32 | Сообщение # 758 |
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| HelenMof | Дата: Вторник, 27.09.2016, 14:41 | Сообщение # 764 |
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